.gwas,.gwas-mount,.gwas-embed,.gwas-studies{--gwas-line:color-mix(in srgb, currentColor 14%, transparent);--gwas-soft:color-mix(in srgb, currentColor 5%, transparent);--gwas-muted-c:color-mix(in srgb, currentColor 62%, transparent);--gwas-radius:8px;--gwas-gap:1.25rem}.gwas{display:block}.gwas-mount{position:relative;display:block}.gwas-mount.is-loading:empty::after,.gwas-locus.is-loading .gwas-canvas::after{content:"";position:absolute;inset:0;border-radius:var(--gwas-radius);background:linear-gradient(90deg,transparent,var(--gwas-soft),transparent)0 0/50% 100% no-repeat;animation:gwas-shimmer 1.1s linear infinite;pointer-events:none}@keyframes gwas-shimmer{from{background-position:-50% 0}to{background-position:150% 0}}@media(prefers-reduced-motion:reduce){.gwas-mount.is-loading:empty::after,.gwas-locus.is-loading .gwas-canvas::after{animation:none}}.gwas-head{margin-bottom:var(--gwas-gap)}.gwas-head h1{margin-bottom:.25em}.gwas-crumbs{font-size:.9em;margin-bottom:.25rem;color:var(--gwas-muted-c)}.gwas-crumbs a{text-decoration:none}.gwas-lede{font-size:1.05em;color:var(--gwas-muted-c);margin:.25rem 0 .75rem}.gwas-facts{display:flex;flex-wrap:wrap;gap:.5rem 1.75rem;margin:.75rem 0;padding:0}.gwas-facts>div{min-width:0}.gwas-facts dt{font-size:.8em;color:var(--gwas-muted-c);margin:0;font-weight:500}.gwas-facts dd{margin:0;font-size:1.05em;font-variant-numeric:tabular-nums;font-weight:600}.gwas-facts dt span{cursor:help}.gwas-actions,.gwas-downloads{display:flex;flex-wrap:wrap;gap:.5rem;align-items:center}.gwas-note{padding:.6rem .8rem;border:1px dashed var(--gwas-line);border-radius:var(--gwas-radius)}.gwas-btn{display:inline-flex;align-items:center;gap:.35em;font:inherit;font-size:.875rem;line-height:1.2;padding:.4rem .75rem;border:1px solid var(--gwas-line);border-radius:999px;background:0 0;color:inherit;text-decoration:none;cursor:pointer;white-space:nowrap}.gwas-btn[hidden]{display:none}.gwas-btn:hover{background:var(--gwas-soft)}.gwas-btn:focus-visible,.gwas-input:focus-visible,.gwas-table tr.is-link:focus-visible,.gwas-table th:focus-visible{outline:2px solid var(--sci-accent,var(--gwas-accent,currentColor));outline-offset:2px}.gwas-btn small{color:var(--gwas-muted-c)}.gwas-btn-quiet{border-color:transparent;padding-inline:.4rem}.gwas-btn-group{display:inline-flex}.gwas-btn-group .gwas-btn{border-radius:0;margin-left:-1px;min-width:2.2rem;justify-content:center}.gwas-btn-group .gwas-btn:first-child{border-radius:999px 0 0 999px}.gwas-btn-group .gwas-btn:last-child{border-radius:0 999px 999px 0}.gwas-input{font:inherit;font-size:.9rem;color:inherit;background:0 0;padding:.4rem .7rem;border:1px solid var(--gwas-line);border-radius:var(--gwas-radius);min-width:0}.gwas-input[type=search]{flex:1 1 16rem;max-width:30rem}select.gwas-input{flex:initial;max-width:18rem}select.gwas-input option{color:initial}.gwas-toolbar{display:flex;flex-wrap:wrap;gap:.5rem;align-items:center;margin:0 0 .75rem}.gwas-toolbar label{display:inline-flex;gap:.4rem;align-items:center;font-size:.9rem}.gwas-status{font-size:.85rem}.gwas-search{margin-top:.75rem}.gwas-section{margin:var(--gwas-gap)0}.gwas-section>h2{font-size:1.1em;margin:0 0 .5rem;display:flex;align-items:baseline;gap:.5em}.gwas-grid{display:grid;grid-template-columns:minmax(260px,340px)minmax(0,1fr);gap:0 2rem;align-items:start}@media(max-width:760px){.gwas-grid{grid-template-columns:minmax(0,1fr)}}.gwas-hint{font-size:.85rem;color:var(--gwas-muted-c);margin:0 0 .4rem}.gwas-muted{color:var(--gwas-muted-c)}.gwas-count{font-size:.8em;font-weight:500;color:var(--gwas-muted-c);font-variant-numeric:tabular-nums}.gwas-error{color:#c0392b;font-size:.9rem}.gwas-prose{margin:var(--gwas-gap)0}.gwas-id{font-size:.8em;opacity:.7}.gwas-canvas{position:relative;width:100%}.gwas-canvas canvas{display:block;width:100%;touch-action:manipulation}.gwas-tip{position:absolute;left:0;top:0;z-index:5;pointer-events:none;max-width:18rem;padding:.45rem .6rem;font-size:.8rem;line-height:1.4;border-radius:6px;background:var(--gwas-tip-bg,Canvas);color:var(--gwas-tip-fg,CanvasText);border:1px solid var(--gwas-line);box-shadow:0 4px 16px rgb(0 0 0/.12);font-variant-numeric:tabular-nums}.gwas-tip i{font-style:italic}.gwas-legend{list-style:none;display:flex;flex-wrap:wrap;gap:.25rem 1rem;padding:0;margin:.4rem 0;font-size:.8rem}.gwas-legend li{display:inline-flex;align-items:center;gap:.35rem;margin:0}.gwas-legend-row{min-height:1.6rem}.gwas-swatch{display:inline-block;width:.7rem;height:.7rem;border-radius:50%;flex:none;vertical-align:-.05em;margin-right:.3em}.gwas-legend .gwas-swatch{margin:0}.gwas-diamond{border-radius:1px;transform:rotate(45deg)scale(.85)}.gwas-ring{background:0 0;border:2px solid}.gwas-locus{position:relative}.gwas-selected{display:flex;flex-wrap:wrap;gap:.25rem .5rem;align-items:center;min-height:2rem;font-size:.9rem;font-variant-numeric:tabular-nums}.gwas-chip{font-size:.75rem;padding:.1rem .5rem;border-radius:999px;background:var(--gwas-soft);border:1px solid var(--gwas-line)}.gwas-table-wrap{overflow-x:auto}.gwas-table{width:100%;border-collapse:collapse;font-size:.875rem;font-variant-numeric:tabular-nums;margin:0}.gwas-table th,.gwas-table td{padding:.45rem .6rem;text-align:left;border:0;border-bottom:1px solid var(--gwas-line);vertical-align:baseline}.gwas-table th{font-weight:600;font-size:.8rem;color:var(--gwas-muted-c);cursor:pointer;user-select:none;white-space:nowrap;background:0 0}.gwas-table th[aria-sort=ascending]::after{content:" ▲";font-size:.7em}.gwas-table th[aria-sort=descending]::after{content:" ▼";font-size:.7em}.gwas-table .num{text-align:right;white-space:nowrap}.gwas-table tbody tr{background:0 0}.gwas-table tbody tr:hover,.gwas-table tr.is-link:focus{background:var(--gwas-soft)}.gwas-table tr.is-link{cursor:pointer}.gwas-table a{text-decoration:none;font-weight:500}.gwas-table-tools{display:flex;flex-wrap:wrap;gap:.5rem;align-items:center;margin-bottom:.5rem}.gwas-table-tools[hidden]{display:none}.gwas-table-wrap>.gwas-btn{margin-top:.5rem}.gwas-cards{display:grid;grid-template-columns:repeat(auto-fill,minmax(240px,1fr));gap:.75rem}.gwas-card{display:flex;flex-direction:column;gap:.2rem;padding:.8rem .9rem .5rem;border:1px solid var(--gwas-line);border-radius:var(--gwas-radius);color:inherit;text-decoration:none;transition:border-color .15s,background .15s}.gwas-card:hover{background:var(--gwas-soft);border-color:color-mix(in srgb,currentColor 30%,transparent)}.gwas-card.is-static:hover{background:inherit;border-color:inherit}.gwas-preview-note{margin:0 0 1.25rem;padding:.55rem .8rem;font-size:.9rem;border-left:3px solid var(--gwas-accent,currentColor);background:var(--gwas-soft)}.gwas-preview-tag{font-weight:600;text-transform:uppercase;letter-spacing:.04em;font-size:.72em}.gwas-card-title{font-weight:600}.gwas-card-meta{font-size:.8rem;color:var(--gwas-muted-c)}.gwas-mini{margin-top:.35rem;min-height:64px;pointer-events:none}.gwas-studies{list-style:none;padding:0;margin:var(--gwas-gap)0}.gwas-study-item{padding:.9rem 0;border-bottom:1px solid var(--gwas-line);margin:0}.gwas-study-title{font-weight:600;font-size:1.1em;text-decoration:none}.gwas-study-meta{display:block;font-size:.85rem;color:var(--gwas-muted-c)}.gwas-study-item p{margin:.35rem 0 0}.gwas-embed{margin:1.5rem 0}.gwas-embed-head{font-size:.9rem;margin-bottom:.25rem}.gwas-embed-head a{font-weight:600;text-decoration:none}.gwas-embed-qq{max-width:380px}.gwas-gallery{display:grid;grid-template-columns:repeat(auto-fill,minmax(220px,1fr));gap:1rem}.gwas-gallery figure,.gwas-figure{margin:0}.gwas-gallery img,.gwas-figure img{display:block;width:100%;height:auto;border-radius:calc(var(--gwas-radius)/2);border:1px solid var(--gwas-line);background:#fff}.gwas-gallery figcaption,.gwas-figure figcaption{font-size:.8rem;color:var(--gwas-muted-c);margin-top:.3rem}.gwas-figure{margin:1.25rem 0}.gwas-subhead{font-size:1rem;margin:1.2rem 0 .3rem}.gwas-ldsc-note{margin-top:.35rem}.gwas-ldsc-note span[title]{cursor:help;text-decoration:underline dotted;text-underline-offset:.2em}.gwas-embed-head.has-cohorts,.gwas-hint.has-cohorts{display:flex;flex-wrap:nowrap;align-items:flex-start;gap:.15rem 1rem}.gwas-head-text{flex:1;min-width:0}.gwas-cohorts{display:flex;flex-wrap:wrap;justify-content:flex-end;gap:4px 12px;align-items:center;margin:0 10px 6px 0}.gwas-cohorts.in-head{flex:initial;max-width:50%;margin:0 0 0 auto;padding-top:.2rem}@media(max-width:40rem){.gwas-embed-head.has-cohorts,.gwas-hint.has-cohorts{flex-wrap:wrap}.gwas-cohorts.in-head{flex-basis:100%;max-width:none;justify-content:flex-start;padding-top:0}}.gwas-plot-note{padding-left:46px}.gwas-cohorts.is-foot{align-items:baseline;margin-top:-14px}.gwas-cohorts.is-foot .gwas-maf-note{margin:0 auto 0 0}.gwas-cohorts.is-bottom{margin:6px 10px 0 0}.gwas-cohorts-name{margin-right:auto;font-size:12px;opacity:.75}.gwas-cohort{display:inline-flex;align-items:center;gap:5px;height:18px;padding:0;color:var(--gwas-muted-c,currentColor);opacity:.85;font-family:inherit;font-weight:600;font-size:11px;line-height:1;letter-spacing:.02em;text-decoration:none;white-space:nowrap}a.gwas-cohort:hover,a.gwas-cohort:focus-visible{color:var(--sci-accent,var(--gwas-accent,currentColor));opacity:1}.gwas-cohorts.is-pill{gap:6px}.is-pill .gwas-cohort{height:22px;padding:0 9px;opacity:1;border:1.5px solid var(--sci-accent,var(--gwas-accent,currentColor));border-radius:var(--gwas-cohort-radius,999px);color:var(--sci-accent,var(--gwas-accent,currentColor));background:var(--gwas-tip-bg,Canvas)}.is-pill .gwas-cohort.is-icon{padding:0 6px}.is-pill a.gwas-cohort:hover,.is-pill a.gwas-cohort:focus-visible{background:var(--sci-accent,var(--gwas-accent,currentColor));color:var(--gwas-tip-bg,Canvas)}.gwas-cohort-icon{display:inline-block;background:currentColor;-webkit-mask:var(--icon)center/contain no-repeat;mask:var(--icon)center/contain no-repeat}.gwas-cohort-img{display:block}.gwas-sources{margin:2rem 0 1rem}.gwas-sources-title{font-size:1rem;margin:0 0 .6rem}.gwas-sources ul{list-style:none;margin:0;padding:0;display:grid;grid-template-columns:repeat(auto-fill,minmax(15rem,1fr));gap:.6rem}.gwas-source{display:flex;gap:.6rem;align-items:center;padding:.55rem .75rem;border:1.5px solid var(--sci-accent,var(--gwas-accent,currentColor));border-radius:var(--gwas-cohort-radius,12px)}.gwas-source-icon{flex:none;width:2.2rem;height:1.6rem;color:var(--sci-accent,var(--gwas-accent,currentColor))}.gwas-source-img{flex:none;width:2.2rem;height:1.6rem;object-fit:contain}.gwas-source-text{display:flex;flex-direction:column;min-width:0;line-height:1.25;font-weight:600}.gwas-source-text a{color:inherit;text-decoration:none}.gwas-source-text a:hover,.gwas-source-text a:focus-visible{text-decoration:underline;text-underline-offset:.2em}.gwas-source-desc{font-weight:400;font-size:.85em;opacity:.75}.gwas-embed .gwas-table-wrap.is-compact .gwas-table{font-size:.8rem;line-height:1.3}.gwas-embed .gwas-table-wrap.is-compact .gwas-table th{font-size:.72rem;padding:.25rem .5rem .25rem 0}.gwas-embed .gwas-table-wrap.is-compact .gwas-table td{font-size:.8rem;line-height:1.3;padding:.2rem .5rem .2rem 0}.gwas-embed .gwas-table-wrap.is-compact .gwas-table td a{font-size:1em;line-height:inherit;font-weight:600}.gwas-embed .gwas-table-wrap.is-compact .gwas-table td:first-child{max-width:22rem;overflow:hidden;text-overflow:ellipsis;white-space:nowrap}.gwas-embed .gwas-table-wrap.is-tiny .gwas-table,.gwas-embed .gwas-table-wrap.is-tiny .gwas-table td{font-size:.7rem;line-height:1.2}.gwas-embed .gwas-table-wrap.is-tiny .gwas-table th{font-size:.65rem;padding:.1rem .4rem .1rem 0}.gwas-embed .gwas-table-wrap.is-tiny .gwas-table td{padding:.08rem .4rem .08rem 0}article.gwas:not(.has-wrap){max-width:var(--gwas-width,64rem);margin-inline:auto;padding:1.5rem 1rem 3rem;box-sizing:border-box}article.gwas.has-wrap{padding-block:1.5rem 3rem}.gwas-group{margin:1.4rem 0}.gwas-group-title{font-size:1.15rem;margin:0 0 .6rem}details.gwas-group>summary{cursor:pointer;font-weight:600;padding:.4rem 0}.gwas-paper{margin:.2rem 0 1rem;opacity:.85}.gwas-card.is-secondary,.gwas-table tr.is-secondary{opacity:.6}.gwas-card.is-secondary:hover,.gwas-table tr.is-secondary:hover{opacity:1}.gwas-card.is-secondary .gwas-card-title::after,.gwas-table tr.is-secondary td:first-child a::after{content:"secondary";margin-left:.5em;font-size:.7em;font-weight:400;text-transform:uppercase;letter-spacing:.04em;opacity:.8}:root{--sci-accent:var(--link);--sci-cat:#1d4aa8, #e8379e, #e09a00, #1baf7a, #6250d6, #e34948;--sci-seq:#f7cfe5, #f0a3cf, #e46fb4, #cc2f8d, #8f0f5e;--gwas-ld:var(--sci-seq);--gwas-line:var(--rule);--gwas-soft:var(--paper-2);--gwas-muted-c:var(--ink-3);--gwas-radius:0;--gwas-chrom-a:var(--plate-b);--gwas-chrom-b:var(--plate-p);--gwas-index:var(--plate-b);--gwas-tip-bg:var(--paper);--gwas-tip-fg:var(--ink)}:root[data-theme=dark]{--sci-cat:#3987e5, #e04a9e, #c98500, #199e70, #9085e9, #e66767;--sci-seq:#4a1e3c, #7a2a5f, #b23c89, #e85fb0, #ffaedb}@media(prefers-color-scheme:dark){:root:not([data-theme=light]){--sci-cat:#3987e5, #e04a9e, #c98500, #199e70, #9085e9, #e66767;--sci-seq:#4a1e3c, #7a2a5f, #b23c89, #e85fb0, #ffaedb}}.gwas-mount,.gwas-embed,.gwas-facts,.gwas-btn,.gwas-input,.gwas-table,.gwas-card,.gwas-tip,.gwas-legend,.gwas-hint,.gwas-preview-note,.gwas-study-meta,.gwas-section>h2,.gwas-table-tools{font-family:var(--display);font-stretch:100%}.gwas-intro .intro-meta{margin-top:22px}.gwas-intro .gwas-facts{margin:0;gap:8px 32px}.gwas-intro .gwas-facts dt{font-size:13px;font-weight:600;color:var(--ink-3)}.gwas-intro .gwas-facts dd{font-size:20px;font-weight:700;color:var(--ink)}.gwas-intro .gwas-actions{margin-top:22px}.gwas-intro .gwas-search{margin:0}.gwas-intro .eyebrow a{color:inherit;text-decoration:none}.gwas-intro .eyebrow a:hover{text-decoration:underline}.gwas-btn{border:1.5px solid var(--ink);border-radius:0;font-weight:600;color:var(--ink)}.gwas-btn:hover{background:var(--accent);border-color:var(--accent);color:var(--on-accent)}.gwas-btn-quiet{border-color:transparent;text-decoration:underline;text-underline-offset:.2em}.gwas-btn-quiet:hover{background:0 0;border-color:transparent;color:var(--pink-text)}.gwas-btn-group .gwas-btn,.gwas-btn-group .gwas-btn:first-child,.gwas-btn-group .gwas-btn:last-child{border-radius:0}.gwas-input{border:1.5px solid var(--ink);border-radius:0;background:var(--paper)}.gwas-input:focus{outline:2px solid var(--accent);outline-offset:2px}.gwas-section{margin:clamp(40px,6vw,72px)0 0}.gwas-section>h2{font-size:clamp(24px,2.6vw,32px);font-weight:var(--dw);letter-spacing:-.02em;padding-bottom:12px;border-bottom:2px solid var(--ink);margin-bottom:18px}.gwas-viewer>.gwas-section:first-child{margin-top:0}.gwas-table th,.prose .gwas-table th{color:var(--ink-3);font-size:14px;font-weight:600;border-bottom:2px solid var(--ink);padding:10px 14px 10px 0}.gwas-table td,.prose .gwas-table td,.prose .gwas-table td:first-child{color:var(--ink);font-family:var(--display);font-weight:400;white-space:normal;padding:12px 14px 12px 0;border-bottom:1px solid var(--rule);vertical-align:baseline}.gwas-table-wrap.is-compact .gwas-table th,.prose .gwas-table-wrap.is-compact .gwas-table th{font-size:12px;padding:6px 12px 6px 0}.gwas-table-wrap.is-compact .gwas-table td,.prose .gwas-table-wrap.is-compact .gwas-table td,.prose .gwas-table-wrap.is-compact .gwas-table td:first-child{font-size:13px;line-height:1.3;padding:5px 12px 5px 0}.gwas-table-wrap.is-compact .gwas-table td:first-child,.prose .gwas-table-wrap.is-compact .gwas-table td:first-child{white-space:nowrap}.gwas-table-wrap.is-tiny .gwas-table th,.prose .gwas-table-wrap.is-tiny .gwas-table th{font-size:11px;padding:3px 10px 3px 0}.gwas-table-wrap.is-tiny .gwas-table td,.prose .gwas-table-wrap.is-tiny .gwas-table td,.prose .gwas-table-wrap.is-tiny .gwas-table td:first-child{font-size:12px;line-height:1.2;padding:2px 10px 2px 0}.gwas-table td a,.prose .gwas-table td a{color:var(--ink);font-size:inherit;font-weight:600;text-decoration:none}.gwas-table td a:hover{color:var(--pink-text);text-decoration:underline}.gwas-table tbody tr:hover{background:var(--paper-2)}.gwas-card{border:1.5px solid var(--ink);border-radius:0;background:var(--paper)}.gwas-card:hover{background:var(--paper);border-color:var(--ink);box-shadow:4px 4px 0 var(--accent)}.gwas-card-title{font-family:var(--display);font-weight:700;font-size:19px}.gwas-tip{border:1.5px solid var(--ink);border-radius:0;box-shadow:3px 3px 0 var(--accent)}.gwas-studies{border-top:2px solid var(--ink)}.gwas-study-title{font-family:var(--display);font-size:22px;color:var(--ink)}.gwas-study-title:hover{color:var(--pink-text)}.prose .gwas-embed{margin:2em 0}.prose .gwas-legend,.prose .gwas-studies{padding-left:0}.prose .gwas-legend li{margin:0}.prose .gwas-gallery img,.prose .gwas-figure img{margin:0}.gwas-embed-head a{color:var(--ink)}.gwas-embed-head a:hover{color:var(--pink-text)}.gwas-chip{border-radius:0;border-color:var(--ink);font-family:var(--display)}.gwas>.prose{margin-top:clamp(48px,7vw,88px)}.gwas>.prose:first-child{margin-top:0;margin-bottom:clamp(32px,5vw,56px)}.gwas-gallery figcaption{font-family:var(--text);font-style:italic}.gwas-intro .gwas-actions>.gwas-mount{flex:1 1 100%}.gwas-intro .gwas-search .gwas-input{flex:0 1 32rem}:root[data-palette=gem]{--sci-cat:#233e8f, #e09a00, #1baf7a, #6aa0e8, #6250d6, #e34948;--sci-seq:#dbe8fa, #a9c8f2, #6aa0e8, #2d6bc9, #14337a}:root[data-palette=gem][data-theme=dark]{--sci-cat:#5b94f0, #e0a61a, #35c48f, #9ec1f7, #9085e9, #e66767;--sci-seq:#14337a, #2d6bc9, #6aa0e8, #a9c8f2, #dbe8fa}@media(prefers-color-scheme:dark){:root[data-palette=gem]:not([data-theme=light]){--sci-cat:#5b94f0, #e0a61a, #35c48f, #9ec1f7, #9085e9, #e66767;--sci-seq:#14337a, #2d6bc9, #6aa0e8, #a9c8f2, #dbe8fa}}